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Challenges in Clinical Electrocardiography.O and P, T1-weighted coronal images show progression of central and perisylvian atrophy (arrow) from baseline (O) to follow-up (P). K-N, Baseline (K and M) and follow-up (L and N) axial diffusion-weighted images show decrease in cortical signal abnormality in the occipital lobes (arrowheads) at follow-up (L) compared with baseline (K) and decrease in cortical signal abnormality in the parietal lobes (arrowheads) at follow-up (N) compared with baseline (M). K-P, Shown are axial diffusion-weighted images in a 53-year-old woman with the codon 129 methionine homozygous polymorphism. I and J, Axial diffusion-weighted images in a 60-year-old woman with the codon 129 valine homozygous polymorphism show an increase in caudate and thalamic signal intensity (arrows) from baseline (I) to follow-up 4 months later (J). The arrow in H indicates increased central atrophy on follow-up. G and H, Coronal T1-weighted images show progression of central and parietal atrophy from baseline (G) to follow-up (H). Note that the cortical signal abnormality progresses in contiguous cortical areas. The arrowheads in F indicate increased right superior parietal signal abnormality. E and F, Bifrontal and biparietal cortical signal abnormality (E) progresses to increased right superior parietal cortical signal abnormality at follow-up (F). C and D, Signal intensity 0 in the right putamen at baseline (C) progresses to signal intensity 2 (arrowheads) and new right lateral occipital cortical signal abnormality at follow-up (arrow) (D). A and B, The left temporo-occipital cortical signal abnormality (A) progresses to bilateral temporo-occipital cortical signal abnormality at follow-up 30 months later (arrowhead) (B). A-H, Shown are axial diffusion-weighted images in a 66-year-old woman with the codon 129 methionine valine polymorphism.
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